Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cancer cells in response to therapy-induced hostile environment are largely unknown. As the central organelle for cellular energy supply, mitochondria can rapidly undergo dynamic changes and integrate cellular signaling pathways to provide bioenergetic and biosynthetic flexibility for cancer cells, which contributes to multiple aspects of tumor characteristics, including drug resistance. Therefore, targeting mitochondria for cancer therapy and overcoming drug resistance has attracted increasing attention for various types of cancer. Multiple mitochondrial adaptation processes, including…

• NN
  National Natural Science Foundation of China

  Awards: 2017YFA0503900, 2019B030301009, 82173003, 81821002, 82130082, 82003098, 81790251
• SA
  Science and Technology Planning Project of Guangdong Province
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2019B030302012