Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications

Enzymes are a class of natural catalysts with high efficiency, specificity, and selectivity unmatched by their synthetic counterparts and dictate a myriad of reactions that constitute various cascades in living cells. The development of suitable supports is significant for the immobilization of structurally flexible enzymes, enabling biomimetic transformation in the extracellular environment. Accordingly, porous organic frameworks, including metal organic frameworks (MOFs), covalent organic frameworks (COFs) and hydrogen-bonded organic frameworks (HOFs), have emerged as ideal supports for the immobilization of enzymes because of their structural features including ultrahigh surface area, tailorable porosity,…

• NN
  National Natural Science Foundation of China

  Awards: 22174164, 21904146, 22104159
• NS
  Natural Science Foundation of Guangdong Province

  Awards: 2020A1515010824, 2019A1515011722