Design of Diselenide-Bridged Hyaluronic Acid Nano-antioxidant for Efficient ROS Scavenging to Relieve Colitis
National Center for Nanoscience and Technology · Jilin University · +2 more institutions
Abstract
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel disease (IBD), is responsible for dysregulation of signal transduction, inflammatory response, and DNA damage, which ultimately leads to disease progression and deterioration. Thus, ROS scavenging has become a promising strategy to navigate IBD. Inspired by the targeting capability of hyaluronic acid (HA) to CD44-overexpressed inflammatory cells together with the redox regulation capacity of diselenide compounds, we developed an oral nanoformulation, i.e., diselenide-bridged hyaluronic acid nanogel (SeNG), with a view to treat colitis through a ROS scavenging mechanism. Our data demonstrated that SeNG specifically…
Citation impact
- FWCI
- 15.61
- Percentile
- 100%
- References
- 55
Authors
9- JXJiaqi Xu
National Center for Nanoscience and Technology
- TCTianjiao Chu
Jilin University, National Center for Nanoscience and Technology
- TYTingting Yu
Peking University
- NLNaishi Li
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- CWChunling Wang
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
Topics & keywords
- Reactive oxygen species
- Colitis
- Inflammatory bowel disease
- Chemistry
- Antioxidant
- Hyaluronic acid
- Ulcerative colitis
- CD44
- Life below water