articleCancer ResearchJul 21, 2022Closed access

Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer

ETEleonora TimperiPGPaul GueguenMMMartina MolgoraIMIlaria MagagnaYKYann Kieffer

Inserm · Université Paris Sciences et Lettres · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Tumor-associated macrophages (TAM) play a detrimental role in triple-negative breast cancer (TNBC). In-depth analysis of TAM characteristics and interactions with stromal cells, such as cancer-associated fibroblast (CAF), could provide important biological and therapeutic insights. Here we identify at the single-cell level a monocyte-derived STAB1+TREM2high lipid-associated macrophage (LAM) subpopulation with immune suppressive capacities that is expanded in patients resistant to immune checkpoint blockade (ICB). Genetic depletion of this LAM subset in mice suppressed TNBC tumor growth. Flow cytometry and bulk RNA sequencing data demonstrated that coculture with TNBC-derived CAFs led to reprogramming of blood…

Citation impact

267
total citations
FWCI
20.78
Percentile
100%
References
46
Citations per year

Authors

20

Topics & keywords

Topics
Keywords
  • Immune system
  • Cancer research
  • Tumor microenvironment
  • Stromal cell
  • Breast cancer
  • Cancer
  • Cancer-Associated Fibroblasts
  • Macrophage
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding