Molecular Biomarkers in Cancer
University of Helsinki · Helsinki University Hospital · +1 more institution
Abstract
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer, occurrence of cancer, or patient outcome. They may include germline or somatic genetic variants, epigenetic signatures, transcriptional changes, and proteomic signatures. These indicators are based on biomolecules, such as nucleic acids and proteins, that can be detected in samples obtained from tissues through tumor biopsy or, more easily and non-invasively, from blood (or serum or plasma), saliva, buccal swabs, stool, urine, etc. Detection technologies have advanced tremendously over the last decades, including techniques such as next-generation sequencing, nanotechnology, or methods to study circulating tumor DNA/RNA or…
Citation impact
- FWCI
- 40.06
- Percentile
- 100%
- References
- 184
Authors
2Topics & keywords
- Liquid biopsy
- Cancer biomarkers
- Cancer
- Medicine
- Computational biology
- Biomarker
- Biomarker discovery
- Molecular diagnostics