reviewBiomoleculesJul 23, 2022GOLD OA

Molecular Biomarkers in Cancer

University of Helsinki · Helsinki University Hospital · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer, occurrence of cancer, or patient outcome. They may include germline or somatic genetic variants, epigenetic signatures, transcriptional changes, and proteomic signatures. These indicators are based on biomolecules, such as nucleic acids and proteins, that can be detected in samples obtained from tissues through tumor biopsy or, more easily and non-invasively, from blood (or serum or plasma), saliva, buccal swabs, stool, urine, etc. Detection technologies have advanced tremendously over the last decades, including techniques such as next-generation sequencing, nanotechnology, or methods to study circulating tumor DNA/RNA or…

Citation impact

434
total citations
FWCI
40.06
Percentile
100%
References
184
Citations per year

Authors

2

Topics & keywords

Keywords
  • Liquid biopsy
  • Cancer biomarkers
  • Cancer
  • Medicine
  • Computational biology
  • Biomarker
  • Biomarker discovery
  • Molecular diagnostics
No related works found for this paper.

Funding