reviewFluids and Barriers of the CNSJul 25, 2022GOLD OA

Extracellular vesicles through the blood–brain barrier: a review

HMHéctor M. Ramos‐ZaldívarIPIva PolakovičováESEdison Salas‐HuenuleoAHAlejandro H. CorvalánMJMarcelo J. Kogan

Pontificia Universidad Católica de Chile · Advanced Center for Chronic Diseases · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood-Brain barrier (BBB) in a bidirectional manner between the bloodstream and brain parenchyma remains poorly understood. Most in vitro models that have evaluated this event have relied on monolayer transwell or microfluidic organ-on-a-chip techniques that do not account for the combined effect of all cellular layers that constitute the BBB at different sites of the Central Nervous System. There has not been direct transcytosis visualization through the BBB in mammals in vivo, and evidence comes from in vivo experiments in zebrafish. Literature is…

Citation impact

261
total citations
FWCI
20.10
Percentile
100%
References
88
Citations per year

Authors

7

Topics & keywords

Topics
Keywords
  • Transcytosis
  • Blood–brain barrier
  • Microvesicles
  • Neuroscience
  • In vivo
  • Zebrafish
  • Extracellular vesicles
  • Biology
No related works found for this paper.

Funding