articlePsychopharmacology BulletinAug 12, 2025Closed access

Interventional Approaches to Pain and Spasticity Related to Cerebral Palsy

Georgetown University · Mount Sinai Medical Center · +1 more institution

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Abstract

Purpose of Review This review will cover seminal and emerging evidence on interventional therapy chronic pain in cerebral palsy (CP). It will cover the background and burden of disease, present the current options, and then weigh the evidence that is available to support interventional therapy and the current indications. Recent Findings CP is a permanent posture and movement disorder from in-utero brain development defects with a 3–4/1,000 incidence in the US. The cost of care for each child is estimated at $921,000. Pain in CP is attributed to musculoskeletal deformities, spasticity, increased muscle tone, dislocations, and GI dysfunction. First-line treatments include physical and occupational therapy and…

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