reviewCellsJul 25, 2022GOLD OA

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

LSLei SuYGYunhuan GaoRYRongcun Yang

Nankai University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such as indole-3-lactate (ILA), indole-3-acrylate (IAC), indole-3-propionate (IPA), indole-3-aldehyde (IAID), indoleacetic acid (IAA), indole-3-acetaldehyde and Kyn can be produced by intestinal microorganisms through direct Trp transformation and also, partly, the kynurenine (Kyn) pathway. These metabolites play a critical role in maintaining the homeostasis of the gut and systematic immunity and also potentially affect the occurrence and development of diseases such as inflammatory bowel diseases, tumors, obesity and metabolic…

Citation impact

369
total citations
FWCI
20.54
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100%
References
178
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Authors

3

Topics & keywords

Topics
Keywords
  • Kynurenine
  • Tryptophan
  • Indole test
  • Gut flora
  • Kynurenine pathway
  • Quinolinic acid
  • Inflammation
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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