Akkermansia muciniphila phospholipid induces homeostatic immune responses
Gachon University · Harvard University · +8 more institutions
Abstract
Abstract Multiple studies have established associations between human gut bacteria and host physiology, but determining the molecular mechanisms underlying these associations has been challenging 1–3 . Akkermansia muciniphila has been robustly associated with positive systemic effects on host metabolism, favourable outcomes to checkpoint blockade in cancer immunotherapy and homeostatic immunity 4–7 . Here we report the identification of a lipid from A. muciniphila ’s cell membrane that recapitulates the immunomodulatory activity of A. muciniphila in cell-based assays 8 . The isolated immunogen, a diacyl phosphatidylethanolamine with two branched chains (a15:0-i15:0 PE), was characterized through both…
Citation impact
- FWCI
- 29.98
- Percentile
- 100%
- References
- 53
Authors
15- MBMunhyung BaeCorresponding
Gachon University, Harvard University, Boston VA Research Institute
- CDChelsi D. Cassilly
Harvard University, Boston VA Research Institute
- XLXiaoxi Liu
Harvard University, Boston VA Research Institute, Dana-Farber Cancer Institute
- SPSung‐Moo Park
Broad Institute, Harvard University, Massachusetts General Hospital
- BKBetsabeh Khoramian Tusi
Broad Institute, Harvard University, Massachusetts General Hospital
Topics & keywords
- Akkermansia muciniphila
- TLR2
- Immune system
- Biology
- Cell biology
- Immunogen
- Chemistry
- Biochemistry
- Good health and well-being