A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Abstract Cuproptosis is a very newly recognized regulated cell death modality that is distinct from known death mechanisms and shows enormous prospect in cancer treatment. However, its efficacy is copper‐dependent and restricted by strictly regulated copper metabolism. Herein, a novel copper/iron hybrid hollow amorphous metal organic framework (HaMOF) is developed as an oxidative stress amplifier and copper/iron metabolic disrupter for synergistic cuproptosis/ferroptosis/apoptosis anticancer therapy. The HaMOF is fabricated from Cu 2+ , 3,3′‐dithiobis(propionohydrazide) and Fe 3+ via an unsaturated coordination‐etching integration strategy, and then doxorubicin is loaded followed by surface decoration with…

• NN
  National Natural Science Foundation of China

  Awards: 820733095, 5210030542
• CP
  China Postdoctoral Science Foundation

  Awards: 2019M663743, 2019TQ0256
• WJ
  Wu Jieping Medical Foundation

  Awards: 320.6750.2020‐01‐15, 320.6750.2021‐16‐11
• FR
  Fundamental Research Funds for the Central Universities

  Award: xjh012020036