reviewACS NanoAug 2, 2022GREEN OA

Quantitative Phase Imaging: Recent Advances and Expanding Potential in Biomedicine

TLThang L. NguyenSPSoorya PradeepRLRobert L. Judson‐TorresJRJason ReedMAMichael A. Teitell

University of California, Los Angeles · University of Utah · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with significant opportunities for biomedical applications. QPI uses the natural phase shift of light as it passes through a transparent object, such as a mammalian cell, to quantify biomass distribution and spatial and temporal changes in biomass. Reported in cell studies more than 60 years ago, ongoing advances in QPI hardware and software are leading to numerous applications in biology, with a dramatic expansion in utility over the past two decades. Today, investigations of cell size, morphology, behavior, cellular viscoelasticity, drug efficacy, biomass accumulation and turnover, and transport mechanics are supporting studies…

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294
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38.52
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100%
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Authors

6

Topics & keywords

Topics
Keywords
  • Phase imaging
  • Biomedicine
  • Nanotechnology
  • Scope (computer science)
  • Regenerative medicine
  • Computer science
  • Biology
  • Materials science
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