A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma
Beijing Proteome Research Center · State Key Laboratory of Proteomics · +4 more institutions
Abstract
Abstract Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and tumor development. Here, we generate a single-cell atlas of the multicellular ecosystem of HCC from four tissue sites. We show the enrichment of central memory T cells (T CM ) in the early tertiary lymphoid structures (E-TLSs) in HCC and assess the relationships between chronic HBV/HCV infection and T cell infiltration and exhaustion. We find the MMP9 + macrophages to be terminally differentiated tumor-associated macrophages (TAMs) and PPARγ to be the pivotal transcription factor driving their differentiation. We also characterize the heterogeneous subpopulations of malignant hepatocytes and…
Citation impact
- FWCI
- 41.31
- Percentile
- 100%
- References
- 59
Authors
13- YLYiming Lu
Beijing Proteome Research Center, State Key Laboratory of Proteomics
- AYAiqing Yang
Beijing Proteome Research Center, State Key Laboratory of Proteomics
- CQCheng Quan
Beijing Proteome Research Center, State Key Laboratory of Proteomics
- YPYingwei Pan
Chinese PLA General Hospital
- HZHaoyun Zhang
Chinese PLA General Hospital
Topics & keywords
- Tumor microenvironment
- Hepatocellular carcinoma
- Cancer research
- Immune system
- Malignancy
- Biology
- Multicellular organism
- Cell