Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Abstract Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN 4 , VN 4 , and Fe-Cu-N 6 with catalytic activities surpassing natural enzymes. Notably, Rh/VN 4 preferably forms an Rh/V-O-N 4 active center to decrease reaction energy barriers and mediates a “two-sided oxygen-linked” reaction path, showing 4 and 5-fold higher affinities in peroxidase-like activity than the FeN 4 and natural horseradish peroxidase. Furthermore, RhN 4 presents a 20-fold improved affinity in the catalase-like activity compared to the…

• NN
  National Natural Science Foundation of China

  Awards: 91859101, 11804248, U1932107, 82001952, 81971744
• TU
  Tianjin University
• NS
  Natural Science Foundation of Tianjin City

  Awards: 11804248, 2021FJ-0009, 19JCZDJC34000, 20JCYBJC00940
• NK
  National Key Research and Development Program of China

  Award: 2021YFF1200700