Spatial multi-omic map of human myocardial infarction

Myocardial infarction is a leading cause of death worldwide 1 . Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies to reduce late-stage mortality 2 . Here we generate an integrative high-resolution map of human cardiac remodelling after myocardial infarction using single-cell gene expression, chromatin accessibility and spatial transcriptomic profiling of multiple physiological zones at distinct time points in myocardium from patients with myocardial infarction and controls. Multi-modal data integration enabled us to evaluate cardiac cell-type compositions at increased resolution, yielding insights into changes of…

• DF
  Deutsche Forschungsgemeinschaft

  Awards: SFBTRR219, 454024652, INST 37/935-1, 37/935-1, 37/935-1 FUGG, 445703531, CRU344, CRU5011, 322900939, INST 37/935-1 FUGG
• FL
  Fondation Leducq
• EK
  Eberhard Karls Universität Tübingen
• BF
  Bundesministerium für Bildung und Forschung

  Awards: BMBF 01ZZ2004, 01ZZ2004
• N
  Nierstichting

  Award: TASKFORCE EP1805
• EK
  Else Kröner-Fresenius-Stiftung
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Award: VIDI 09150172010072
• RA
  RWTH Aachen University

  Award: SFBTRR219
• KT
  Klaus Tschira Stiftung