NF-κB: blending metabolism, immunity, and inflammation

The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the need to maintain metabolic homeostasis. NF-κB transcription factors are central regulators of immunity and inflammation. Over the last two decades, these factors have emerged as a pivotal node coordinating the immune and metabolic systems in physiology and the etiopathogenesis of major threats to human health, including cancer, autoimmunity, chronic inflammation, and others. In this review, we discuss recent advances in understanding how NF-κB-dependent metabolic…

• CD
  Compagnia di San Paolo
• CR
  Cancer Research UK

  Awards: C26587, C26587/A8839
• NI
  National Institute for Health and Care Research
• MR
  Medical Research Council

  Awards: MR/V027581/1, MR/V027581/1, 07_DG_2022_02
• NI
  NIHR Imperial Biomedical Research Centre

  Award: P81135