Spatially resolved clonal copy number alterations in benign and malignant tissue

Abstract Defining the transition from benign to malignant tissue is fundamental to improving early diagnosis of cancer 1 . Here we use a systematic approach to study spatial genome integrity in situ and describe previously unidentified clonal relationships. We used spatially resolved transcriptomics 2 to infer spatial copy number variations in >120,000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate. Our results suggest a model for how genomic instability arises in histologically benign tissue that may…

• A
  AstraZeneca
• CR
  Cancer Research UK

  Award: C57899/A25812
• NI
  National Institute for Health and Care Research
• EC
  European Commission

  Award: 101021019
• SF
  Stiftelsen för Strategisk Forskning
• C
  Cancerfonden
• SF
  Science for Life Laboratory
• LV
  Landstinget Västmanland
• JB
  John Black Charitable Foundation
• NO
  NIHR Oxford Biomedical Research Centre