Regulated cell death (RCD) in cancer: key pathways and targeted therapies

Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the form of cell death that can be regulated by a variety of biomacromolecules, which is distinctive from accidental cell death (ACD). Accumulating evidence has revealed that RCD subroutines are the key features of tumorigenesis, which may ultimately lead to the establishment of different potential therapeutic strategies. Hitherto, targeting the subroutines of RCD with pharmacological small-molecule compounds has been emerging as a promising therapeutic avenue, which has rapidly progressed in many types of human cancers. Thus, in this review, we focus on summarizing not only the key apoptotic and autophagy-dependent cell…

• CA
  China Association for Science and Technology

  Awards: CACM-2020-QNRC1-01, QNRC1-01
• NN
  National Natural Science Foundation of China

  Awards: 82073998, 82003879, 81773889
• JD
  Jiangsu Development and Reform Commission
• DO
  Department of Science and Technology of Sichuan Province

  Award: 2022JDRC0045
• SU
  Sichuan University

  Awards: 82003879, ZYJC21061
• WC
  West China Hospital, Sichuan University

  Awards: ZYJC21061, 1.3.5