articleNature CommunicationsAug 16, 2022GOLD OA

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity

LDLijun DongJXJingwen XieYWYouyi WangHJHonglian JiangKCKai Chen

Southern Medical University · Nanfang Hospital · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is involved in metabolism and synthesis of glycoproteins, exhibits anti-inflammatory and anti-oxidative activities. We show here that the circulating level of mannose is increased in patients with IBD and mice with experimental colitis. Mannose treatment attenuates intestinal barrier damage in two mouse colitis models, dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis in IL-10-deficient mice. We demonstrate that mannose treatment enhanced lysosomal integrity and limited the release of cathepsin B, preventing mitochondrial…

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251
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Authors

17

Topics & keywords

Topics
Keywords
  • Colitis
  • Mannose
  • Inflammatory bowel disease
  • Intestinal mucosa
  • Chemistry
  • Immunology
  • Medicine
  • Biochemistry
UN Sustainable Development Goals
  • Good health and well-being
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