Systemic inflammation after stroke: implications for post‐stroke comorbidities

Immunological mechanisms have come into the focus of current translational stroke research, and the modulation of neuroinflammatory pathways has been identified as a promising therapeutic approach to protect the ischemic brain. However, stroke not only induces a local neuroinflammatory response but also has a profound impact on systemic immunity. In this review, we will summarize the consequences of ischemic stroke on systemic immunity at all stages of the disease, from onset to long-term outcome, and discuss underlying mechanisms of systemic brain-immune communication. Furthermore, since stroke commonly occurs in patients with multiple comorbidities, we will also overview the current understanding of the…

• DF
  Deutsche Forschungsgemeinschaft

  Awards: FOR 2879 (LI‐2534/5‐1), SI 2832/1‐1, EXC 2145 SyNergy ‐ ID 390857198
• SZ
  Stiftung zur Erforschung der Vaskulären Demenz
• HE
  HORIZON EUROPE European Research Council

  Award: ERC‐StGs 802305