Tumor‐Microenvironment‐Responsive Cascade Reactions by a Cobalt‐Single‐Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy
National Center for Nanoscience and Technology · University of Chinese Academy of Sciences · +4 more institutions
Abstract
Abstract Nanocatalytic therapy, involving the nanozyme‐triggered production of reactive oxygen species (ROS) in the tumor microenvironment (TME), has demonstrated potential in tumor therapy, but nanozymes still face challenges of activity and specificity that compromise the therapeutic efficacy. Herein, we report a strategy based on a single‐atom nanozyme to initiate cascade enzymatic reactions in the TME for tumor‐specific treatment. The cobalt‐single‐atom nanozyme, with Co−N coordination on N‐doped porous carbon (Co‐SAs@NC), displays catalase‐like activity that decomposes cellular endogenous H 2 O 2 to produce O 2 , and subsequent oxidase‐like activity that converts O 2 into cytotoxic superoxide radicals to…
Citation impact
- FWCI
- 16.88
- Percentile
- 100%
- References
- 71
Authors
9- SCShuangfei CaiCorresponding
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- JLJiaming Liu
University of North Carolina at Chapel Hill, North Carolina State University, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- JDJianwei Ding
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- ZFZhao Fu
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- HLHaolin Li
Sino-Danish Centre for Education and Research, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
Topics & keywords
- Cascade
- Chemistry
- Cobalt
- Chemotherapy
- Medicine
- Inorganic chemistry
- Internal medicine