reviewJournal of NeuroinflammationAug 17, 2022GOLD OA

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease

DSDeepali Singh

National Brain Research Centre

PubMed
Indexed incrossrefdoajpubmed

Abstract

Neuroinflammation is instigated by the misfiring of immune cells in the central nervous system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a consequence of CNS injury, infection, toxicity, or autoimmunity. It is favorable as well as a detrimental process for neurodevelopment and associated processes. Transient activation of inflammatory response involving release of cytokines and growth factors positively affects the development and post-injury tissue. However, chronic or uncontrolled inflammatory responses may lead to various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and multiple sclerosis.…

Citation impact

509
total citations
FWCI
36.55
Percentile
100%
References
165
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Authors

1

Topics & keywords

Topics
Keywords
  • Neuroinflammation
  • Microglia
  • Astrocyte
  • Immune system
  • Neuroscience
  • Immunology
  • Biology
  • Central nervous system
UN Sustainable Development Goals
  • Good health and well-being
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