Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet-induced obesity and diabetes. The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and L-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate,…

• CF
  Canon Foundation in Europe
• JA
  Japan Agency for Medical Research and Development

  Awards: JP19KA3001, 20H05697, 22gm1010006h0004, 22ae0121035s0102, 22ae0121042h0002, 17ek0210078h0002
• MO
  Ministry of Education, Culture, Sports, Science and Technology
• UO
  University of Tokyo
• OM
  Ono Medical Research Foundation
• NI
  National Institutes of Biomedical Innovation, Health and Nutrition
• JS
  Japan Society for the Promotion of Science

  Awards: 17H04134, 20K11560, 18K17997, 21K15267, 20K08534, 20H04117, 16K00944, 18H02674, 18H02150, 20H05697, 22K15004, 19K07617
• IO
  Institute of Medical Science, University of Tokyo