SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma

Abstract Radioresistance is a principal culprit for the failure of radiotherapy in hepatocellular carcinoma (HCC). Insights on the regulation genes of radioresistance and underlying mechanisms in HCC are awaiting for profound investigation. In this study, the suppressor of cytokine signaling 2 (SOCS2) were screened out by RNA-seq and bioinformatics analyses as a potential prognosis predictor of HCC radiotherapy and then were determined to promote radiosensitivity in HCC both in vivo or in vitro. Meanwhile, the measurements of ferroptosis negative regulatory proteins of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), intracellular lipid peroxidation and Fe 2+ concentration…

• NN
  National Natural Science Foundation of China

  Awards: 32171235, 31770910, 12175044, 11775052
• SA
  Science and Technology Commission of Shanghai Municipality

  Award: 19411950902
• SJ
  Shanghai Jiao Tong University
• RH
  Ruijin Hospital
• SO
  School of Medicine, Shanghai Jiao Tong University