articleNature GeneticsAug 11, 2022GREEN OA

A multi-tissue atlas of regulatory variants in cattle

SLShuli LiuYGYahui GaoOCOriol Canela‐XandriSWSheng WangYYYing Yu

Agricultural Research Service · Westlake University · +18 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Characterization of genetic regulatory variants acting on livestock gene expression is essential for interpreting the molecular mechanisms underlying traits of economic value and for increasing the rate of genetic gain through artificial selection. Here we build a Cattle Genotype–Tissue Expression atlas (CattleGTEx) as part of the pilot phase of the Farm animal GTEx (FarmGTEx) project for the research community based on 7,180 publicly available RNA-sequencing (RNA-seq) samples. We describe the transcriptomic landscape of more than 100 tissues/cell types and report hundreds of thousands of genetic associations with gene expression and alternative splicing for 23 distinct tissues. We evaluate the tissue-sharing…

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Topics & keywords

Topics
Keywords
  • Biology
  • Atlas (anatomy)
  • Computational biology
  • Genetics
  • Regulatory sequence
  • Evolutionary biology
  • Regulation of gene expression
  • Gene
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