New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Natural products, and especially the active ingredients found in traditional Chinese medicine (TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such, traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used…

• NN
  National Natural Science Foundation of China

  Awards: 91853109, 81872877, 81730100, 82073975
• NU
  Nanjing University
• NS
  Natural Science Research of Jiangsu Higher Education Institutions of China

  Award: 22KJB360005
• FR
  Fundamental Research Funds for the Central Universities

  Award: 020814380174
• SO
  School of Life Sciences and Biotechnology Division of Life Sciences, Korea University