mobileOG-db: a Manually Curated Database of Protein Families Mediating the Life Cycle of Bacterial Mobile Genetic Elements

The analysis of bacterial mobile genetic elements (MGEs) in genomic data is a critical step toward profiling the root causes of antibiotic resistance, phenotypic or metabolic diversity, and the evolution of bacterial genera. Existing methods for MGE annotation pose high barriers of biological and computational expertise to properly harness. To bridge this gap, we systematically analyzed 10,776,849 proteins derived from eight databases of MGEs to identify 6,140 MGE protein families that can serve as candidate hallmarks, i.e., proteins that can be used as "signatures" of MGEs to aid annotation. The resulting resource, mobileOG-db, provides a multilevel classification scheme that encompasses plasmid, phage,…

• NS
  National Science Foundation

  Awards: 1545756, 2125798, 2004751
• UD
  U.S. Department of Agriculture

  Award: 2017-68003-26498
• WR
  Water Research Foundation
• NI
  National Institute of Food and Agriculture

  Award: 2017-68003-26498
• DO
  Division of Graduate Education

  Award: 2125798