New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
University of Oslo · Akershus University Hospital · +23 more institutions
Abstract
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other…
Citation impact
- FWCI
- 25.34
- Percentile
- 100%
- References
- 61
Authors
21- TSTomas Schmauck‐MedinaCorresponding
University of Oslo, Akershus University Hospital
- AMAdrian Molière
University of Oslo, Akershus University Hospital
- SLSofie Lautrup
University of Oslo, Akershus University Hospital
- JZJianying Zhang
University of Oslo, Akershus University Hospital
- SCStefan Chłopicki
Jagiellonian University
Topics & keywords
- Ageing
- Gerontology
- History
- Medicine
- Zero hunger