Inflammation: Roles in Skeletal Muscle Atrophy

Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation, mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced proteolysis. The underlying mechanism of inflammation in skeletal muscle atrophy is extremely complex and has not been fully elucidated, thus hindering the development of effective therapeutic drugs and preventive measures for skeletal muscle atrophy. In this review, we elaborate on protein degradation pathways, including the ubiquitin-proteasome system (UPS), the autophagy-lysosome pathway (ALP), the calpain and caspase pathways, the insulin growth factor 1/Akt protein synthesis pathway, myostatin, and muscle satellite cells, in the process of…

• NN
  National Natural Science Foundation of China

  Awards: 82072160, 32130060, BK20202013, 81901933, 20KJA310012, BK20201209
• GO
  Government of Jiangsu Province
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: BK20202013, BK20202013, BK20201209, BK20201209, 32130060
• NU
  Nantong University
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions

  Awards: 32130060, BK20202013