Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use
University of Agriculture in Krakow · Jagiellonian University
Abstract
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its consequences still remain a significant problem in medicine. Acute inflammatory responses are responsible for directly life-threating conditions such as septic shock; on the other hand, chronic inflammation can cause degeneration of body tissues leading to severe impairment of their function. Neuroinflammation is defined as an inflammatory response in the central nervous system involving microglia, astrocytes, and cytokines including chemokines. It is considered an important cause of neurodegerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Lipopolysaccharide (LPS) is a…
Citation impact
- FWCI
- 23.27
- Percentile
- 100%
- References
- 130
Authors
2Topics & keywords
- Neuroinflammation
- Lipopolysaccharide
- Action (physics)
- Neuroscience
- Computational biology
- Chemistry
- Risk analysis (engineering)
- Biochemical engineering
- Good health and well-being