reviewJournal of Ovarian ResearchSep 1, 2022GOLD OA

The role of oxidative stress in ovarian aging: a review

FYFei YanQZQi ZhaoYLYing LiZZZhibo ZhengXKXinliang Kong

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

PubMed
Indexed incrossrefdoajpubmed

Abstract

Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is considered to be a key factor. This review focuses on the fact that OS status accelerates the ovarian aging process by promoting apoptosis, inflammation, mitochondrial damage, telomere shortening and biomacromolecular damage. Current evidence suggests that aging, smoking, high-sugar diets, pressure, superovulation, chemotherapeutic agents and industrial pollutants can be factors that accelerate ovarian aging by exacerbating OS status. In addition, we review the role of nuclear factor E2-related factor 2 (Nrf2), Sirtuin (Sirt),…

Citation impact

268
total citations
FWCI
45.68
Percentile
100%
References
255
Citations per year

Authors

8

Topics & keywords

Topics
Keywords
  • Oxidative stress
  • Medicine
  • Melatonin
  • Sirtuin
  • Klotho
  • Protein kinase B
  • Sirtuin 1
  • Premature ovarian failure
UN Sustainable Development Goals
  • Good health and well-being
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