HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
Harvard University · Massachusetts General Hospital · +3 more institutions
Abstract
Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient chimerism and reversible capillary leak syndrome developed in all recipients. Irreversible humoral rejection occurred in one patient. In the other four recipients, it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation, and renal function has remained stable for 2.0 to 5.3 years since transplantation. The T cells from these four recipients, tested in vitro, showed donor-specific unresponsiveness and in specimens from allograft biopsies, obtained…
Citation impact
- FWCI
- 64.17
- Percentile
- 100%
- References
- 28
Authors
20- TKTatsuo KawaiCorresponding
Harvard University, Massachusetts General Hospital
- ABA. Benedict Cosimi
Massachusetts General Hospital, Harvard University
- TRThomas R. Spitzer
Massachusetts General Hospital, Harvard University
- NTNina Tolkoff-Rubin
Massachusetts General Hospital, Harvard University
- MSManikkam Suthanthiran
NewYork–Presbyterian Hospital, Cornell University, New York Hospital Queens
Topics & keywords
- Medicine
- Immunosuppression
- Human leukocyte antigen
- Transplantation
- Histocompatibility Testing
- Tacrolimus
- Immunology
- Kidney transplantation
- Zero hunger