On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

The administration of drugs to the central nervous system (CNS) is primarily controlled by the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds from the blood to the brain's extracellular fluid. Although currently available treatments for brain diseases that affect millions of people globally are partially effective, they are associated with severe side effects of systemic drug distribution. On the other hand, the ability of certain drugs to permeate through the BBB is impeded by their physicochemical properties, achieving sub-therapeutic concentrations in their target tissues. In this sense, the intranasal route with its unique anatomical features provides a promising…

• UN
  Universidad Nacional de Córdoba
• CN
  Consejo Nacional de Investigaciones Científicas y Técnicas
• AN
  Agencia Nacional de Investigación y Desarrollo

  Awards: 3200384, 15130011
• FN
  Fondo Nacional de Desarrollo Científico y Tecnológico

  Award: 15130011