reviewChemical ReviewsSep 6, 2022HYBRID OA

Toward Next Generation Lateral Flow Assays: Integration of Nanomaterials

ASAmadeo Sena‐TorralbaRÁRuslán Álvarez-DidukCPClaudio ParoloAPAndrew PiperAMArben Merkoçi

Universitat de València · Institut Català de Nanociència i Nanotecnologia · +4 more institutions

PubMed
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Abstract

Lateral flow assays (LFAs) are currently the most used point-of-care sensors for both diagnostic (e.g., pregnancy test, COVID-19 monitoring) and environmental (e.g., pesticides and bacterial monitoring) applications. Although the core of LFA technology was developed several decades ago, in recent years the integration of novel nanomaterials as signal transducers or receptor immobilization platforms has brought improved analytical capabilities. In this Review, we present how nanomaterial-based LFAs can address the inherent challenges of point-of-care (PoC) diagnostics such as sensitivity enhancement, lowering of detection limits, multiplexing, and quantification of analytes in complex samples. Specifically, we…

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329
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Authors

5

Topics & keywords

Topics
Keywords
  • Commercialization
  • Nanotechnology
  • Nanomaterials
  • Point-of-care testing
  • Point of care
  • Biochemical engineering
  • Chemistry
  • Computer science
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