The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Sichuan University · State Key Laboratory of Biotherapy
Abstract
Epithelial-mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis, including promoted migration and invasiveness, increased tumor stemness, and enhanced resistance to chemotherapy and immunotherapy. EMT is tightly regulated by a complex network which is orchestrated with several intrinsic and extrinsic factors, including multiple transcription factors, post-translational control, epigenetic modifications, and noncoding RNA-mediated regulation. In this review, we described the molecular mechanisms, signaling pathways, and the…
Citation impact
- FWCI
- 88.82
- Percentile
- 100%
- References
- 312
Authors
3Topics & keywords
- Metastasis
- Epigenetics
- Carcinogenesis
- Epithelial–mesenchymal transition
- Cancer research
- Tumor progression
- Biology
- Immunotherapy
- Good health and well-being