articleBrainSep 10, 2022BRONZE OA

Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease

SJShorena JanelidzeDBDivya BaliNJNicholas J. AshtonNRNicolas R. BarthélemyJVJeroen Vanbrabant

Lund University · King's College London · +13 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Plasma phospho-tau (p-tau) species have emerged as the most promising blood-based biomarkers of Alzheimer's disease. Here, we performed a head-to-head comparison of p-tau181, p-tau217 and p-tau231 measured using 10 assays to detect abnormal brain amyloid-β (Aβ) status and predict future progression to Alzheimer's dementia. The study included 135 patients with baseline diagnosis of mild cognitive impairment (mean age 72.4 years; 60.7% women) who were followed for an average of 4.9 years. Seventy-one participants had abnormal Aβ-status (i.e. abnormal CSF Aβ42/40) at baseline; and 45 of these Aβ-positive participants progressed to Alzheimer's dementia during follow-up. P-tau concentrations were determined in…

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Topics & keywords

Topics
Keywords
  • Disease
  • Head (geology)
  • Alzheimer's disease
  • Medicine
  • Neuroscience
  • Psychology
  • Pathology
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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