Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these…

• NN
  National Natural Science Foundation of China

  Awards: No. 81821002, No. 81790251, 81821002, 2020YFC2002705, 82003098, 82103168, 81790251, 82102738
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: No. 2019B030302012, 2019B030302012