reviewMolecular CancerSep 13, 2022GOLD OA

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

ZLZhengjun LinYWYanlin WuYXYiting XuGLGuoqing LiZLZhihong Li

Central South University · Second Xiangya Hospital of Central South University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes and chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studies have indicated that MSCs play critical roles in cancer biology. The crosstalk between tumour cells and MSCs has been found to regulate many tumour behaviours, such as proliferation, metastasis and epithelial-mesenchymal transition (EMT). Multiple lines of evidence have demonstrated that MSCs can secrete exosomes that can modulate the tumour microenvironment and play important roles in tumour development. Notably,…

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274
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21.57
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100%
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Authors

6

Topics & keywords

Topics
Keywords
  • Microvesicles
  • Mesenchymal stem cell
  • Cancer research
  • Biology
  • Metastasis
  • Regenerative medicine
  • Tumor microenvironment
  • Cancer stem cell
UN Sustainable Development Goals
  • Good health and well-being
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