Genetics and Pathogenesis of Parkinson's Syndrome
Baylor College of Medicine · Neurological Research Institute · +3 more institutions
Abstract
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous, resisting distillation to a single, cohesive disorder. Instead, each affected individual develops a virtually unique form of Parkinson's syndrome. Clinical manifestations consist of variable motor and nonmotor features, and myriad overlaps are recognized with other neurodegenerative conditions. Although most commonly characterized by alpha-synuclein protein pathology throughout the central and peripheral nervous systems, the distribution varies and other pathologies commonly modify PD or trigger similar manifestations. Nearly all PD is genetically influenced. More than 100 genes or genetic loci have been identified, and most…
Citation impact
- FWCI
- 42.95
- Percentile
- 100%
- References
- 202
Authors
5- HYHui YeCorresponding
Baylor College of Medicine, Neurological Research Institute, Texas Children's Hospital
- LRLaurie Robak
Baylor College of Medicine, Neurological Research Institute, Texas Children's Hospital
- MYMeigen Yu
Baylor College of Medicine, Neurological Research Institute, Texas Children's Hospital
- MDMatthew D. Cykowski
Methodist Hospital, Methodist Hospital
- JSJoshua Shulman
Baylor College of Medicine, Neurological Research Institute, Texas Children's Hospital
Topics & keywords
- Parkinson's disease
- Neuroscience
- Pathogenesis
- Disease
- Genetic architecture
- Genetic heterogeneity
- Biology
- Alpha-synuclein
- Good health and well-being
Funding
- AAAlzheimer's AssociationAward: AARF-21-848017
- PFParkinson's FoundationAward: PF-PRF-830012
- HMHouston Methodist Hospital
- HFHuffington Foundation
- NINational Institutes of HealthAward: U01AG072439
- HMHouston Methodist Research Institute
- NINational Institute of Neurological Disorders and StrokeAwards: RF1NS118584, F31NS115364