reviewFoodsSep 15, 2022GOLD OA

Health Benefits and Side Effects of Short-Chain Fatty Acids

RXRuo-Gu XiongDZDan-Dan ZhouSWSi-Xia WuSHSiyu HuangASAdila Saimaiti

Sun Yat-sen University · University of Hong Kong · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

The gut microbiota and their metabolites could play an important role in health and diseases of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome fermentation of dietary fiber and could also be produced by bacteria of the skin and vagina. Acetate, propionate, and butyrate are three major SCFAs, and their bioactivities have been widely studied. The SCFAs have many health benefits, such as anti-inflammatory, immunoregulatory, anti-obesity, anti-diabetes, anticancer, cardiovascular protective, hepatoprotective, and neuroprotective activities. This paper summarizes health benefits and side effects of SCFAs with a special attention paid to the mechanisms of action. This paper…

Citation impact

396
total citations
FWCI
29.28
Percentile
100%
References
121
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Butyrate
  • Health benefits
  • Propionate
  • Functional food
  • Human health
  • Dietary fiber
  • Microbiome
  • Gut microbiome
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding