reviewNature MedicineSep 1, 2022HYBRID OA

Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases

GIGianluca IaniroMPMichal PunčochářNKNicolai KarcherSPSerena PorcariFAFederica Armanini

Università Cattolica del Sacro Cuore · Agostino Gemelli University Polyclinic · +5 more institutions

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Abstract

Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides difficile infection and is considered a promising treatment for other microbiome-related disorders, but a comprehensive understanding of microbial engraftment dynamics is lacking, which prevents informed applications of this therapeutic approach. Here, we performed an integrated shotgun metagenomic systematic meta-analysis of new and publicly available stool microbiomes collected from 226 triads of donors, pre-FMT recipients and post-FMT recipients across eight different disease types. By leveraging improved metagenomic strain-profiling to infer strain sharing, we found that recipients with higher donor strain…

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334
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100%
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23

Topics & keywords

Topics
Keywords
  • Microbiome
  • Metagenomics
  • Firmicutes
  • Fecal bacteriotherapy
  • Biology
  • Transplantation
  • Dysbiosis
  • Bacteroidetes
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