Manganese‐Based Tumor Immunotherapy

Abstract As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles in host immune system, hematopoiesis, endocrine function, and oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible and show versatile applications in nanomedicine, in particular utilized in tumor immunotherapy in the following ways: 1) acting as a biocompatible nanocarrier to deliver immunotherapeutic agents for tumor immunotherapy; 2) serving as an adjuvant to regulate tumor immune microenvironment and enhance immunotherapy; 3) activating host's immune system through the cGAS‐STING pathway to trigger tumor immunotherapy; 4) real‐time monitoring…

• NN
  National Natural Science Foundation of China

  Awards: 51825302, 51802202, 21807074
• NS
  Natural Science Foundation of Chongqing