Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease
Toho University · Juntendo University · +2 more institutions
Abstract
Background and Objectives The glymphatic system is a whole-brain perivascular network, which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal role in amyloid β (Aβ) accumulation. However, its involvement in Alzheimer disease (AD) pathogenesis is not fully understood. Here, we investigated the changes in noninvasive MRI measurements related to the perivascular network in patients with mild cognitive impairment (MCI) and AD. Additionally, we explored the associations of MRI measures with neuropsychological score, PET standardized uptake value ratio (SUVR), and Aβ deposition. Methods MRI measures, including perivascular space (PVS) volume fraction (PVSVF), fractional volume…
Citation impact
- FWCI
- 27.26
- Percentile
- 100%
- References
- 47
Authors
18- KKKoji KamagataCorresponding
Toho University, Juntendo University, Toho University Omori Medical Center, Nagoya University
- CAChristina Andica
Toho University, Juntendo University, Toho University Omori Medical Center, Nagoya University
- KTKaito Takabayashi
Toho University, Juntendo University, Toho University Omori Medical Center, Nagoya University
- YSYuya Saito
Toho University, Juntendo University, Toho University Omori Medical Center, Nagoya University
- TTToshiaki Taoka
Toho University, Juntendo University, Toho University Omori Medical Center, Nagoya University
Topics & keywords
- Glymphatic system
- Cognition
- Association (psychology)
- Disease
- Cognitive impairment
- Medicine
- Amyloid (mycology)
- Alzheimer's disease
Funding
- UDU.S. Department of DefenseAwards: U01 AG024904, W81XWH, W81XWH-12-2-, W81XWH-12-2-0012, AG024904
- FFFoundation for the National Institutes of HealthAwards: W81XWH-12-2-0012, Grant U01 AG024904, AG024904, U01 AG024904
- AAAlzheimer's AssociationAwards: U01 AG024904, W81XWH-12-2-0012
- BSBristol-Myers SquibbAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- ELEli Lilly and CompanyAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- PPfizerAwards: AG024904, W81XWH-12-2-0012, U01 AG024904
- BBiogenAwards: W81XWH-12-2-0012, U01 AG024904, AG024904
- UOUniversity of Southern CaliforniaAwards: W81XWH-12-2-0012, U01 AG024904
- FHF. Hoffmann-La RocheAwards: W81XWH-12-2-0012, AG024904, U01 AG024904
- MSMeso Scale DiagnosticsAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- ADAlzheimer's Disease Neuroimaging InitiativeAwards: AG024904, W81XWH-12-2-, W81XWH-12-2-0012, Department of Defense award number W81XWH-12-2-0012, U01 AG024904
- BBioClinicaAwards: U01 AG024904, W81XWH-12-2-0012, AG024904
- NPNovartis Pharmaceuticals CorporationAwards: W81XWH-12-2-0012, U01 AG024904, AG024904
- JAJapan Agency for Medical Research and DevelopmentAwards: JP21wm0425006, JP19dm0307101
- NCNorthern California Institute for Research and EducationAwards: U01 AG024904, W81XWH-12-2-0012
- CMCanon Medical Systems Corporation
- EEisaiAwards: W81XWH-12-2-0012, U01 AG024904, AG024904
- SServierAwards: AG024904, W81XWH-12-2-0012, U01 AG024904
- PAPromotion and Mutual Aid Corporation for Private Schools of Japan
- HLH. Lundbeck A/SAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- IIXICOAwards: AG024904, W81XWH-12-2-0012, U01 AG024904
- NINational Institutes of HealthAwards: AG024904, U01 AG024904, W81XWH, Grant U01 AG024904, W81XWH-12-2-0012
- GGenentechAwards: W81XWH-12-2-0012, AG024904, U01 AG024904
- CICanadian Institutes of Health ResearchAwards: U01 AG024904, W81XWH-12-2-0012
- JSJapan Society for the Promotion of ScienceAwards: 19K17244, 16H06280, 19K08161, 20K16737, 18K07730, 18H02772, JP16H06280, JP18H02772, 21K07629, 21K07563
- NINational Institute on AgingAwards: U01 AG024904, W81XWH-12-2-0012, AG024904
- NINational Institute of Biomedical Imaging and BioengineeringAwards: W81XWH-12-2-0012, U01 AG024904, AG024904