Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer
Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center · +1 more institution
Abstract
Objective The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing. Here, we aimed to characterise the interactions between gut microbiome, metabolites and microbial enzymes in EO-CRC patients and evaluate their potential as non-invasive biomarkers for EO-CRC. Design We performed metagenomic and metabolomic analyses, identified multiomics markers and constructed CRC classifiers for the discovery cohort with 130 late-onset CRC (LO-CRC), 114 EO-CRC subjects and age-matched healthy controls (97 LO-Control and 100 EO-Control). An independent cohort of 38 LO-CRC, 24 EO-CRC, 22 LO-Controls and 24 EO-Controls was analysed to validate the results. Results Compared with controls, reduced…
Citation impact
- FWCI
- 18.62
- Percentile
- 100%
- References
- 61
Authors
9- CKCheng Kong
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- LLLei Liang
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- GLGuang Liu
- LDLutao Du
Second Hospital of Shandong University
- YYYongzhi Yang
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
Topics & keywords
- Metabolome
- Metabolomics
- KEGG
- Microbiome
- Colorectal cancer
- Biology
- Metagenomics
- Gut flora