articleNature MedicineSep 22, 2022HYBRID OA

Metabolomic profiles predict individual multidisease outcomes

TBThore BuergelJSJakob SteinfeldtGRGreg RuyogaMPMaik PietznerDBDaniele Bizzarri

Berlin Institute of Health at Charité - Universitätsmedizin Berlin · Franklin University · +14 more institutions

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Abstract

Risk stratification is critical for the early identification of high-risk individuals and disease prevention. Here we explored the potential of nuclear magnetic resonance (NMR) spectroscopy-derived metabolomic profiles to inform on multidisease risk beyond conventional clinical predictors for the onset of 24 common conditions, including metabolic, vascular, respiratory, musculoskeletal and neurological diseases and cancers. Specifically, we trained a neural network to learn disease-specific metabolomic states from 168 circulating metabolic markers measured in 117,981 participants with ~1.4 million person-years of follow-up from the UK Biobank and validated the model in four independent cohorts. We found…

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Topics & keywords

Topics
Keywords
  • Metabolomics
  • Medicine
  • Biobank
  • Disease
  • Internal medicine
  • Bioinformatics
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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