Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance
Oregon Health & Science University · University of Pennsylvania
Abstract
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance. Recent advances in tissue imaging capabilities, single-cell analytics, and disease modeling have shed light on organizing principles that shape the stromal complexity of PDAC tumors. These insights into the functional and spatial dependencies that coordinate cancer cell biology and the relationships that exist between cells and extracellular matrix components present in tumors are expected to unveil therapeutic vulnerabilities. We review recent advances in the field and discuss current understandings of…
Citation impact
- FWCI
- 41.91
- Percentile
- 100%
- References
- 165
Authors
2Topics & keywords
- Stromal cell
- Tumor microenvironment
- Pancreatic cancer
- Pathogenesis
- Extracellular matrix
- Cancer research
- Disease
- Pancreatic ductal adenocarcinoma
- Good health and well-being