Current understanding of osteoarthritis pathogenesis and relevant new approaches

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key mediators in OA-associated pain. We then introduce several…

• UO
  University of Rochester
• NN
  National Natural Science Foundation of China

  Awards: 82161160342, 82030067, 82172397
• CA
  Chinese Academy of Sciences
• YI
  Youth Innovation Promotion Association of the Chinese Academy of Sciences

  Award: 2020353
• NI
  National Institutes of Health
• MC
  Medical Center, University of Rochester
• NK
  National Key Research and Development Program of China

  Award: 2021YFB3800800
• YI
  Youth Innovation Promotion Association