reviewMolecular NeurodegenerationSep 24, 2022GOLD OA

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

RFRosalía Fernández‐CalleSCSabine C KoningsJFJavier Frontiñán-RubioJGJuan García‐RevillaLCLluís Camprubí-Ferrer

Lund University · University of Castilla-La Mancha · +4 more institutions

PubMed
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Abstract

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation has become the third hallmark of AD, together with Amyloid-β plaques and neurofibrillary tangles of hyperphosphorylated aggregated tau protein. This review aims to broadly and extensively describe the differential aspects concerning apoE. Starting from the evolution of apoE to how APOE's single-nucleotide polymorphisms affect its structure, function, and involvement during health and disease. This review reflects on how APOE's…

Citation impact

270
total citations
FWCI
29.09
Percentile
100%
References
776
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Authors

12

Topics & keywords

Topics
Keywords
  • Apolipoprotein E
  • Neurology
  • Medicine
  • Disease
  • Pathology
  • Genotype
  • Neuroscience
  • Psychiatry
UN Sustainable Development Goals
  • Good health and well-being
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