A wheat resistosome defines common principles of immune receptor channels
University of Cologne · Max Planck Institute for Plant Breeding Research · +8 more institutions
Abstract
Abstract Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen effectors to trigger immune responses 1 . Indirect recognition of a pathogen effector by the dicotyledonous Arabidopsis thaliana coiled-coil domain containing NLR (CNL) ZAR1 induces the formation of a large hetero-oligomeric protein complex, termed the ZAR1 resistosome, which functions as a calcium channel required for ZAR1-mediated immunity 2–4 . Whether the resistosome and channel activities are conserved among plant CNLs remains unknown. Here we report the cryo-electron microscopy structure of the wheat CNL Sr35 5 in complex with the effector AvrSr35 6 of the wheat stem rust pathogen. Direct effector binding…
Citation impact
- FWCI
- 56.07
- Percentile
- 100%
- References
- 64
Authors
13- AFAlexander FördererCorresponding
University of Cologne, Max Planck Institute for Plant Breeding Research
- ELErtong Li
University of Cologne, Max Planck Institute for Plant Breeding Research
- AWAaron W. Lawson
Max Planck Institute for Plant Breeding Research
- YDYa-nan Deng
Chinese Academy of Sciences, Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences
- YSYue Sun
Center for Life Sciences, Tsinghua University
Topics & keywords
- Biology
- Effector
- Arabidopsis
- Leucine-rich repeat
- Arabidopsis thaliana
- Coiled coil
- Genetics
- Protein domain
- Life in Land
Funding
- AVAlexander von Humboldt-StiftungAward: 390686111
- EMEuropean Molecular Biology Laboratory
- DFDeutsche ForschungsgemeinschaftAwards: EXC-2048, EXC-2048/1, SFB-1403-414786233, 414786233, 390686111, 2048/1
- CAChinese Academy of Sciences
- MMax-Planck-Gesellschaft
- ZUZhengzhou University
- NKNational Key Research and Development Program of ChinaAwards: 2021YFA1300701, 2020YFA0509903