TGF-β in developmental and fibrogenic EMTs

TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs) during development and wound healing and in disease conditions such as fibrosis and cancer. During these processes EMT occurs together with changes in cell proliferation, differentiation, communication, and extracellular matrix remodeling that are orchestrated by multiple signaling inputs besides TGF-β. Chief among these inputs is RAS-MAPK signaling, which is frequently required for EMT induction by TGF-β. Recent work elucidated the molecular basis for the cooperation between the TGF-β-SMAD and RAS-MAPK pathways in the induction of EMT in embryonic, adult and carcinoma epithelial cells. These studies also provided direct…

• MS
  Memorial Sloan-Kettering Cancer Center

  Awards: CA008748, P30-CA008748
• AA
  Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center
• NC
  National Cancer Institute

  Awards: R35-CA252978, CA008748, P30-CA008748