Organocatalytic Enantioselective Synthesis of Axially Chiral Molecules: Development of Strategies and Skeletons
Southern University of Science and Technology
Abstract
ConspectusThe growing importance of axially chiral architectures in different scientific domains has unveiled shortcomings in terms of efficient synthetic access and skeletal variety. This account describes our strategies in answering these challenges within the organocatalytic context where the emergence of bifunctional catalysts such as chiral phosphoric acids (CPAs) has proven invaluable in controlling the sense of axial chirality. The wide occurrence of bi(hetero)aryl skeletons in privileged structures constitutes a strong motivation to devise more effective arylation methods. Our design revolves around modulating the intrinsic nucleophilicity of aromatic amines and alcohols. The first approach involves…
Citation impact
- FWCI
- 25.45
- Percentile
- 100%
- References
- 53
Authors
3Topics & keywords
- Enantioselective synthesis
- Nucleophile
- Chemistry
- Combinatorial chemistry
- Axial chirality
- Aryl
- Chirality (physics)
- Rational design